Which of the following conditions is related to regulatory changes in metabolism?

Hypothyroidism is indeed associated with regulatory changes in metabolism, primarily due to the thyroid gland's role in regulating numerous metabolic processes. The thyroid hormones, mainly thyroxine (T4) and triiodothyronine (T3), play a crucial part in metabolism by influencing how the body uses energy, processes nutrients, and maintains temperature. In hypothyroidism, there is an insufficient production of these hormones, which leads to a decreased metabolic rate. This results in various symptoms such as fatigue, weight gain, and sensitivity to cold, among others.

In contrast, Alzheimer's Disease is primarily a neurodegenerative condition that affects cognitive function rather than metabolism. Urinary Tract Infections (UTIs) are infections that affect the urinary system and do not directly influence metabolic regulation. Fractures, while they may impact metabolic regulation indirectly during the healing process, are largely related to physical injury rather than inherent issues in metabolic regulation. Therefore, hypothyroidism clearly stands out as the condition that directly involves regulatory changes in metabolism.